Immunohistochemistry Catalog

Cyclin D1

Clone: SP4
Cat#: 10074
Immunodetection of Cyclin Dl is useful for separating mantle cell lymphomas (+) from SLL's and small cleaved cell lymphomas (-). Cyclin D , one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of neoplasms. Cyclins govern transitions through distinct phases of the cell cycle by regulating the activity of the cyclin­ dependent kinases. ln mid to late Gl, Cyclin Dl shows maximum expression following growth factor stimulation.
Fixed-embedded human mantle cell lymphoma
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