Cat#: DB 055
Antibody to S100 stains schwannomas, ependymomas, astrogliomas, nevi and almost all malignant melanomas and their metastases. S100 protein is also expressed in the antigen presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes.
Fixed-embedded human neurofibroma
Synaptophysin is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms. Synaptophysin contains four trans-membrane domains that form a hexameric channel or gap junction-like pore.
Fixed-embedded human vegetative ganglion
P/T1 antibody is useful for the detection of TGF-α production in human tumor cells and immunoserological monitoring of progression of malignant tumors.
Fixed-embedded human melanoma
Cat#: DB 089
TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas from the breast, mediastinal germ cell tumors and malignant mesothelioma. It can also be used to differentiate Small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non -small cell lung carcinoma has been associated with aggressive behavior of such neoplasms.
Fixed-embedded human thyroid
This mouse monoclonal antibody labels the cytoplasm of TNF-alpha secreting cells including macrophages.
Fixed-embedded human histiocyta/macrophag
Comparing to the conventional labelled streptavidin-biotin or avidin-biotin complex methods, HISTOLS®-MR-T completely eliminates the potential background due to endogenous biotin activity in biotin-rich tissues.
Fixed-embedded human breast
This mouse monoclonal antibody reacts on WT1 protein, which has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian cystadeno-carcinoma, gonadoblastoma, nephroblastoma and desmoplastic small round cell tumor. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm's tumor and mesothelioma. Lung adenocarcinoma is rarely positive with this antibody.
Fixed-embedded human kidney
β-Catenin is normally found in the cytoplasm of the cell in sub-membranous location. Mutations in the β-Catenin gene result nuclear accumulation of this protein, which has been demonstrated in fibrous abdominal and breast lesions, therefore is useful ín different iating these lesions from other spindle cell proliferations that may occur in these locations.
Fixed-embedded human skin