https://www.immbio.hu/ 2014-11-10T11:25:02+01:00 SobiPro Varga Dávid https://www.immbio.hu/hu/palyazatok/cabcos-2/adatbazis/37-amacr-p504s 2014-11-10T11:25:02+01:00 2014-11-10T11:25:02+01:00 Varga Dávid https://www.immbio.hu/hu/palyazatok/cabcos-2/adatbazis/44-bcl-2-1 Bcl-2 is important protein during the process of apoptosis. The antibody may be useful in the classification of follicular lymphomas and various diffuse lymphoproliferative diseases, and for differential identification of diffuse large B-cell lymphoma versus Burkitt lymphoma/leukemia. 2014-11-10T09:38:58+01:00 1970-01-01T01:00:00+01:00 Varga Dávid https://www.immbio.hu/hu/palyazatok/cabcos-2/adatbazis/77-c-erbb-2-her2-neu This antibody recognizes a c-erbB-2 protein, which is a receptor tyrosine kinase of the c­ erbB family. It is closely related in structure to the epidermal growth factor receptor. C-erbB- 2 oncoprotein is detectable in a proportion of breast and other adenocarcinomas, as well as transitional cell carcinomas. 2014-11-10T10:36:49+01:00 1970-01-01T01:00:00+01:00 Varga Dávid https://www.immbio.hu/hu/palyazatok/cabcos-2/adatbazis/71-cd117-c-kit This antibody reacts with a 145 kDa molecular weight protein, designated as CD117/c-kit. C-kits are transmembrane receptor tyrosine kinases expressed in many tissues and cells and are involved in the development of severa l lineages of stem cells such as germ cells, neuronal crest derived melanocytes and hematopoietic precursor cells. Useful in differentiating gastrointestinal stromal tumors from Kaposi's sarcoma, and tumors of smooth muscle origin. 2014-11-10T10:15:15+01:00 1970-01-01T01:00:00+01:00 Varga Dávid https://www.immbio.hu/hu/palyazatok/cabcos-2/adatbazis/81-cox-2 COX-2 inhibition by nonsteroidal anti­ inflammatory agents has been shown to decrease angiogenesis and tumor grovvth, and promote apoptosis. COX-2 overexpression has been associated with increased microvascular density, and V EGF protein expression in head and neck squamous cell carcinoma and is an indicator of poor prognosis. 2014-11-10T10:38:57+01:00 1970-01-01T01:00:00+01:00