MSH2 protein is involved in the initial recognition of mismatched nucleotides during the post replication mismatch repair process. Loss of MSH2 function leads to the accumulation of replication errors, which in turn may be responsible for the multiple mutations required for multistage carcinogenesis.
Fixed-embedded human colon cancer
Myogenin is a nuclear antigen of myoblasts in developing muscle tissue, and is expressed in tumor cell nuclei of rhabdomyosarcoma and some leiomyosarcomas. Positive nuclear staining may occur in Wilm's tumor. Negative in Ewing sarcomas.
Napsin A is a 35.0 kDa molecular weight aspartic proteinase which is expressed in the lung and involved in processing surfactant protein B (SP-B). It is also expressed in the kidney. This antibody may be a useful tool as a tumor marker for prima ry lung adenocarcinoma. Napsin expression correlates with the differentiation grade of lung adenocarcinoma.
Fixed-embedded human lung adenocarcinoma
NKX2.2 is a transcriptic factor during the neuroendocrine and glial differentation. useful for diagnosis of Ewing sarcoma.
Fixed-embedded human bone marrow
HISTOLS® one step detection systems are enzyme labelled micro-polymers, which detect mouse or/and rabbit or rat immunoglobulins bound to antigens in tissue sections and cytological samples. The production of these reagents is based on a new micropolymer technology which permits to obtain small secondary antibody complexes containing high number of labeling enzyme molecules, resulting intense immunostaining with no background.
Fixed-embedded human skin
Cat#: DB 152
P16 plays an important role in cell cycle regulation by decelerating cells progression from G1 phase to S phase, and therefore acts as a tumor suppressor. Hypermethylation, mutation, or deletion of p16 leads to downregulation of the gene and can lead to cancer through the dysregulation of cell cycle progression. Double staining with Ki-67 can provide insight into cell cycle status.
Fixed-embedded human cervix cancer
p27 is a cyclin dependent kinase, which regulates the G1-S phase transition. Its negativity is the attribute of oncogenesis and tumor progression.
P53 is a tumor suppressor protein. This antibody recognizes a 53 kDa phosphoprotein, identified as p53 suppressor gene productIt reacts with the mutant as well as wild form of p53. Positive nuclear staining with this a ntibody has been shown to be a negative prognostic factor in breast, lung, colorectal, and urothelial carcinoma.
Fixed-embedded human colon cancer
Cat#: DB 134
P63 is a 63 kDa protein. The p63 gene is highly expressed in the basal or progenitor layers of many epithelial tissues. P63 shows remarkable structural similarity to p53 gene. Unlike p53, the p63 gene encodes multiple isotypes with divergent abilities to transactivate p53 reporter genes and induce apoptosis.
Fixed-embedded human prostate
Cat#: DB 229
Cat#: DB 047
P16-D is useful in the identification of testicular germ cell tumors. The antibody shows no cross-reaction with other isoenzymes of alkaline phosphatases.
Fixed-embedded human seminoma
D2-40 is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi's sarcomas and in a subset of angiosarcomas with probable lymphatic differentiation. Podoplanin has also been shown to be expressed in epithelioid mesotheliomas, hemangioblastomas and seminomas.
Fixed-embedded human tonsil
Cat#: DB 109
Cat#: DB 108
PgR is an estrogen-regulated protein. It has been proposed that expression of PgR indicates a responsive ER pathway, and therefore, may predict likely response to endocrine therapy in human breast cancer. A number of studies have shown that PgR determination provides supplementary information to ER, both in predicting response to endocrine therapy and estimating survival.
The antigen is expressed on the brush border of proximal renal tubules and on the luminal surface of Bowman's capsule, as well as in parathyroid parenchymal cells and colloid of thyroid follicles. The antibody is useful for the identification of malignant cells from primary and metastatic renal cell carcinomas.