3/G11 reacts on mGluR protein, which is present in brain, heart, kidneys and also in melanomas from mutant mouse melanocytes. Two types of glutamate receptors exist: ionotropic, and metabotropic receptors. Metabotropic receptors are G-protein coupled receptors, which can activate phospholipases or adenylyf -cyclases, depending on the neuron.
Fixed-embedded rat brain
MLH1 is a mismatch repair gene that is deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition known as Hereditary Non-Polyposis Colon Cancer (HNPCC). The anti-MLH1 antibody is useful in screening patients and families for this condition. Colon cancers that are microsatellite unstable have a better prognosis than their microsatellite stable counterparts.
Fixed-embedded human colon cancer