COX-2 inhibition by nonsteroidal anti inflammatory agents has been shown to decrease angiogenesis and tumor grovvth, and promote apoptosis. COX-2 overexpression has been associated with increased microvascular density, and V EGF protein expression in head and neck squamous cell carcinoma and is an indicator of poor prognosis.
Fixed-embedded human colon cancer
Immunodetection of Cyclin Dl is useful for separating mantle cell lymphomas (+) from SLL's and small cleaved cell lymphomas (-). Cyclin D , one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of neoplasms. Cyclins govern transitions through distinct phases of the cell cycle by regulating the activity of the cyclin dependent kinases. ln mid to late Gl, Cyclin Dl shows maximum expression following growth factor stimulation.
Fixed-embedded human mantle cell lymphoma