This mouse monoclonal antibody reacts on WT1 protein, which has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian cystadeno-carcinoma, gonadoblastoma, nephroblastoma and desmoplastic small round cell tumor. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm's tumor and mesothelioma. Lung adenocarcinoma is rarely positive with this antibody.
Fixed-embedded human kidney
β-Catenin is normally found in the cytoplasm of the cell in sub-membranous location. Mutations in the β-Catenin gene result nuclear accumulation of this protein, which has been demonstrated in fibrous abdominal and breast lesions, therefore is useful in differentiating these lesions from other spindle cell proliferations that may occur in these locations.
Fixed-embedded human skin