This mixture of rabbit monoclonal (13H4) and mouse monoclonal (4A4) antibodies is helpful in distinguishing malignant from benign cells. Combined detection of p504S and p63 is useful for the diagnosis of prostate cancers. P504S is expressed in prostatic adenocarcinomas but not in benign glands. p63 is detectable in benign basal cells of the prostate and in other epithelial tissues. p504S is positive in cytoplasm of malignant and premalignant prostate glands, anti-p63 antibody is positive in benign glandular basal layer nuclei.
Fixed-embedded human prostate