This mixture is a combination of a rabbit monoclonal (SP3) and a rabbit clonal (A24-V) antibody. It recognizes the c-erbB-2 protein on both its extracellular and intracellular domain. c-erbB-2/HER2/neu is a receptor tyrosine kinase of the c-erbB family. It is closely related in structure to the epidermal grovvth factor receptor. c-erbB-2 oncoprotein is detectable in a proportion of breast and other adenocarcinomas, as well as transitional cell carcinomas.
Fixed-embedded human breast cancer