Clone: 1A4
Cat#: 10102
1A4 antibody does not stain cardiac or skeletal muscle; however, it stains myofibroblasts and myoepithelial cells.
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Fixed-embedded human tissue
Clone: M16-L
Cat#: DB 147
M16-L stains alpha smooth muscle actin selectively, which is a commonly expressed by myofibroblasts.
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Fixed-embedded human small intestine
Clone: Ql7-L
Cat#: DB 208
High expression of AMACR (p504S) protein is found in prostatic adenocarcinoma but not in benign prostatic gland. The expression of AMACR (PS04S) is also detected in: high - grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia.
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Fixed-embedded human prostate
Clone: 1/22
Cat#: 10029
1/22 reacts on the intracellular C-terminal AQPl epitope of aquaporins which are members of the Major Intrinsic Protein family.
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Fixed-embedded rat brain
Clone: 4/18
Cat#: 10030
4/18 reacts on the intracellular C-terminal AQP4 epitope of aquaporins, which are members of the Major Intrinsic Protein family.
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Fixed-embedded rat brain
Clone: 14
Cat#: 10073
β-Catenin is normally found in the cytoplasm of the cell in sub-membranous location. Mutations in the β-Catenin gene result nuclear accumulation of this protein, which has been demonstrated in fibrous abdominal and breast lesions, therefore is useful in differentiating these lesions from other spindle cell proliferations that may occur in these locations.
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Fixed-embedded human skin
Clone: P21-A
Cat#: DB 064
Bcl-2 is important protein during the process of apoptosis. The antibody may be useful in the classification of follicular lymphomas and various diffuse lymphoproliferative diseases, and for differential identification of diffuse large B-cell lymphoma versus Burkitt lymphoma/leukemia.
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Fixed-embedded human tonsil
Clone: E28-P
Cat#: 10095
C3d is involved in the regulation of many aspects of the immune response including antigen processing and presentation. The C3d/antigen complex mediates B cell activation.
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Fixed-embedded human Pemphygus vulgaris
Clone: A24-T
Cat#: 10096
Activation of the classical complement pathway starts with binding of an activating substance to the Cl molecule, which activates the Cl sub-units, resulting in cleavage of C4 to C4b releasing C4a in the process. The short-lived C4b molecule can bind covalently to membranes. This process is limited to the immediate vicinity of the Cl complex. Because of the short life of the C4b molecule much of the C4d is free and circulates in serum.
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Fixed-embedded human lymph node
Clone: N26-R
Cat#: 10088
CD3 (also known as T3 complex) is a multimeric protein complex composed of four polypeptide chains funct ioning as three pairs of dimers.It is a T cell co-receptor binding to the T cell receptor (TCR). Both TCR s and CD3 are specific features of cel l s belonging to the T cell lineage.
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Fixed-embedded human colon cancer
Clone: A25-G
Cat#: DB 027
COS is a T-cell antigen also expressed by a range of neoplastic B-cells, e.g. B-cell chronic lymphocytic leukemia (B-CLL), B-cell small lymphocytic lymphoma (B-SLL), and mantle cell lymphoma. COS is expressed on T lymphocyte subsets and is modulated during cellular activation. COS does not react with granulocytes or monocytes.
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Fixed-embedded human tonsil
Clone: C21-Q
Cat#: DB 114
CD7 antigen is a cell surface glycoprotein expressed on the surface of immature and mature T cells, and natural killer cells. While its precise function is not known, there is recent suggestion that the molecule functions as an Fc receptor for IgM. CD7 is the most consistently expressed T cell antigen in lymphoblastic lymphomas and leukaemias, and is therefore a useful marker in identification of such neoplastic proliferations.
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Fixed-embedded human tonsil
Clone: P17-V
Cat#: 10089
CD8 is a transmembrane glycoprotein co­-receptor for the T cell receptor (TCR). CD8 binds to class I MHC protein. Immunohistoch emical staining of CD8 in tissue sections allow the quantitative detection of cytotoxic - suppressor T-lymphocytes.
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Fixed-embedded human colon cancer
Clone: G27-P
Cat#: DB 057
Common acute lymphoblastic leukemia antigen (CALLA / CDlO) immunostaining is a useful marker for the characterization of childhood leukemia and B cell lymphomas. This antibody reacts with antigen of lymphoblastic, Burkitt's, and follicular lymphomas; and chronic myelocytic leukemia. Other non-lymphoid cells that are reactive with CDlO are breast myoepithelial cells, bile canaliculi, neutrophils and small population of bone marrow cells, fetal small intestine epithelium, and normal fibroblasts.
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Fixed-embedded human tonsil
Clone: E26-A
Cat#: DB 211
CD15 is a myelomonocytic antigen expressed by more than 95% of mature peripheral blood eosinophils and neutrophils and is present at low density on circulating monocytes. In lymphoid tissue, CD15 reacts with Reed-Sternberg cells of Hodgkin's disease and with granulocytes. However, CD15 reacts with few tissue macrophages and does not react with dendritic cells.
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Fixed-embedded human Hodgkin's-lymphoma