1.-2. Introduction, phylogenesis of the immune system (innate-, adaptive- and natural immunity). Composition of the immune system. Organs, tissues, cells, molecular components.

1.-2. Introduction, phylogenesis of the immune system (innate-, adaptive- and natural immunity). Composition of the immune system. Organs, tissues, cells, molecular components.

3.-4. Molecular components of the immune system. 1. Antigen recognition molecules: Immunoglobulins, T cell receptor. 2. MHC and antigen presentation

3.-4. Molecular components of the immune system. 1. Antigen recognition molecules: Immunoglobulins, T cell receptor. 2. MHC and antigen presentation.

5. Innate immunity: inflammation, leukocyte migration.

5. Innate immunity: inflammation, leukocyte migration.

6. The complement system.

6.  The complement system.

7. Communication between the cellular components of the immune system. Co-receptors and adhesion molecules.

8. Cytokines and their receptors.

7.-8. Communication between the cellular components of the immune system. Co-receptors and adhesion molecules. Cytokines and their receptors.

9.-10. Genetics of immunoglobulins, organization and expression of antigen receptor genes. Central B-cell development. Central (thymic) T cell development.

9.-10. Genetics of immunoglobulins, organization and expression of antigen receptor genes. Central B-cell development. Central (thymic) T cell development.

11.-12. Humoral immune response. Beginning of the specific immune response: T- and B cell activation. T-dependent and T-indepenedent antigens. Extrafollicular- and germinal center reaction. Affinity maturation. Isotype switch.

11.-12. The humoral immune response

13. Immunological memory. Comparison of the primary- and secondary immune responses.

14. Vaccines

13.-14. Development of immunological memory. Comparison of the primary and secondary immune response. Vaccines.

15. Effector functions of immunoglobulins.

16. Effector mechanisms of cell-mediated immune response (CMI)