1-2. Introduction. Molecular components of the immune system.
3-4. Recognition molecules. Recognition by MHC. Antigen presentation and MHC restriction.
5-6. Communication between the cellular components of the immune system. Adhesion molecules, co-receptors. Microvesicles. Cytokines, chemokines and their receptors.
7. Innate immunity. Inflammatory reaction. Pattern recognition.
9-10. Organization and rearrangement of the antigen receptor genes. Primary B cell development: developmental stages and checkpoints.
11.-12. Central- and peripheral T-cell development.
13.-14. Components of the humoral immune response: extrafollicular reaction and germinal center. Affinity maturation and isotype switch.
15. Effector functions of immunoglobulins.
16. The complement system.
17. Maintenance of the immunological memory and its role in immune response regulation. Comparison of the primary- and secondary immune response.
18. Effector mechanisms of the cell-mediated immune responses.
19-20. Suppression of the immune response. Systemic and local immunity (SALT, MALT).
21-22. Hypersensitive reactions.
23-24. Immunological tolerance. Physiological and pathological autoimmunity. Autoimmune diseases.