Introduction. Requirements of the Department. Historical overview. Composition of the immune system. General characteristics of the immune machinery.
3.-4. Molecular components of immunological recognition. Definition of the antigen. Antibodies, T- and B-cell receptors: molecular structure, functions, subclasses.
5.-6. MHC. Structure, genetics, role in the immunological recognition. Antigen presentation.
7.-8. Communication between the cellular components of the immune system. Co-receptors and adhesion molecules. Cytokines, chemokines and their receptors.
9.-10. Innate immunity: inflammation, leukocyte migration.
13-14. Humoral immune responses: extrafollicular reaction and germinal center. Immunological memory.
15.-16. Production and applications of monoclonal antibodies. Systemic and local immunity.
17.-18. Regulation of effector functions. Antibody-mediated effector functions. Effector mechanisms of the cell-mediated immune response.
19.-20. Suppression of the immune response. Cellular and molecular mechanisms.
23.-24. Immunological tolerance. Physiological and pathological autoimmunity.
25.-26. Autoimmune diseases. Tumor immunology.